Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

[Image: see text] Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer from limited throughput and a poor signal/noise ratio, hamperi...

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Detalles Bibliográficos
Autores principales: Nacheva, Katya, Kulkarni, Sameer S., Kassu, Mintesinot, Flanigan, David, Monastyrskyi, Andrii, Iyamu, Iredia D., Doi, Kenichiro, Barber, Megan, Namelikonda, Niranjan, Tipton, Jeremiah D., Parvatkar, Prakash, Wang, Hong-Gang, Manetsch, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620989/
https://www.ncbi.nlm.nih.gov/pubmed/37000900
http://dx.doi.org/10.1021/acs.jmedchem.3c00108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620989/
https://www.ncbi.nlm.nih.gov/pubmed/37000900
http://dx.doi.org/10.1021/acs.jmedchem.3c00108

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