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Multi-scale characterisation of homologous recombination deficiency in breast cancer
BACKGROUND: Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’. However, these patterns are diff...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621207/ https://www.ncbi.nlm.nih.gov/pubmed/37919776 http://dx.doi.org/10.1186/s13073-023-01239-7 |