MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice

Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of MYC has previously been shown to drive medulloblastoma formation in mice, the functional significance...

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Detalles Bibliográficos
Autores principales: Göbel, Carolin, Godbole, Shweta, Schoof, Melanie, Holdhof, Dörthe, Kresbach, Catena, Loose, Carolin, Neumann, Julia, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621315/
https://www.ncbi.nlm.nih.gov/pubmed/37919824
http://dx.doi.org/10.1186/s40478-023-01654-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621315/
https://www.ncbi.nlm.nih.gov/pubmed/37919824
http://dx.doi.org/10.1186/s40478-023-01654-2

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