Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Wallerian degeneration (WD) is a conserved axonal self-destruction program implicated in several neurological diseases. WD is driven by the degradation of the NAD(+) synthesizing enzyme NMNAT2, the buildup of its substrate NMN, and the activation of the NAD(+) degrading SARM1, eventually leading to...

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Detalles Bibliográficos
Autores principales: Alexandris, Athanasios S., Ryu, Jiwon, Rajbhandari, Labchan, Harlan, Robert, McKenney, James, Wang, Yiqing, Aja, Susan, Graham, David, Venkatesan, Arun, Koliatsos, Vassilis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621467/
https://www.ncbi.nlm.nih.gov/pubmed/35779777
http://dx.doi.org/10.1016/j.nbd.2022.105808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621467/
https://www.ncbi.nlm.nih.gov/pubmed/35779777
http://dx.doi.org/10.1016/j.nbd.2022.105808

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