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Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons
Wallerian degeneration (WD) is a conserved axonal self-destruction program implicated in several neurological diseases. WD is driven by the degradation of the NAD(+) synthesizing enzyme NMNAT2, the buildup of its substrate NMN, and the activation of the NAD(+) degrading SARM1, eventually leading to...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621467/ https://www.ncbi.nlm.nih.gov/pubmed/35779777 http://dx.doi.org/10.1016/j.nbd.2022.105808 |