Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy

Mutations in the NADH dehydrogenase (ubiquinone reductase) iron-sulfur protein 4 (NDUFS4) gene, which encodes for a key structural subunit of the OXFOS complex I (CI), lead to the most common form of mitochondrial disease in children known as Leigh syndrome (LS). As in other mitochondrial diseases,...

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Detalles Bibliográficos
Autores principales: Manning, Arena, Han, Victor, Stephens, Alexa, Wang, Rose, Bush, Nicholas, Bard, Michelle, Ramirez, Jan M., Kalume, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621616/
https://www.ncbi.nlm.nih.gov/pubmed/37704057
http://dx.doi.org/10.1016/j.nbd.2023.106288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621616/
https://www.ncbi.nlm.nih.gov/pubmed/37704057
http://dx.doi.org/10.1016/j.nbd.2023.106288

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