Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors. A significant fraction (25.9%) of somatic RB1 mutations are nonsense substitutions leading to a premature term...

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Detalles Bibliográficos
Autores principales: Palomar-Siles, Mireia, Yurevych, Viktor, Bykov, Vladimir J. N., Wiman, Klas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621805/
https://www.ncbi.nlm.nih.gov/pubmed/37917619
http://dx.doi.org/10.1371/journal.pone.0292468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621805/
https://www.ncbi.nlm.nih.gov/pubmed/37917619
http://dx.doi.org/10.1371/journal.pone.0292468

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