PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma

Drugs targeting cyclin-dependent kinases 4 and 6 (CDK4/6) are promising new treatments for melanoma and other solid malignancies. In studies on CDK4/6 inhibitor resistance, protein arginine methyltransferase 5 (PRMT5) regulation of alternative splicing was shown to be an important downstream compone...

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Detalles Bibliográficos
Autores principales: Chan, Lok Hang, Wang, Peihan, Abuhammad, Shatha, Lim, Lydia Rui Jia, Cursons, Joseph, Sheppard, Karen E., Goode, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621831/
https://www.ncbi.nlm.nih.gov/pubmed/37917641
http://dx.doi.org/10.1371/journal.pone.0292278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621831/
https://www.ncbi.nlm.nih.gov/pubmed/37917641
http://dx.doi.org/10.1371/journal.pone.0292278

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