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PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma
Drugs targeting cyclin-dependent kinases 4 and 6 (CDK4/6) are promising new treatments for melanoma and other solid malignancies. In studies on CDK4/6 inhibitor resistance, protein arginine methyltransferase 5 (PRMT5) regulation of alternative splicing was shown to be an important downstream compone...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621831/ https://www.ncbi.nlm.nih.gov/pubmed/37917641 http://dx.doi.org/10.1371/journal.pone.0292278 |