DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid

Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent show improved efficacy over unmodified PNAs in stimulating recombination-induced gene modification. However, this structur...

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Detalles Bibliográficos
Autores principales: Oyaghire, Stanley N., Quijano, Elias, Perera, J. Dinithi R., Mandl, Hanna K., Saltzman, W. Mark, Bahal, Raman, Glazer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621889/
https://www.ncbi.nlm.nih.gov/pubmed/37920723
http://dx.doi.org/10.1016/j.xcrp.2023.101635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621889/
https://www.ncbi.nlm.nih.gov/pubmed/37920723
http://dx.doi.org/10.1016/j.xcrp.2023.101635

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