Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study
BACKGROUND: To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy. METHODS: In this multicentr...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621933/ https://www.ncbi.nlm.nih.gov/pubmed/37917761 http://dx.doi.org/10.1371/journal.pone.0293883 |
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author | Santos, Mariana M. S. Pereira, Isabel J. Cuboia, Nelson Reis-Pardal, Joana Adrião, Diana Cardoso, Teresa Aragão, Irene Santos, Lurdes Sarmento, António Rosa, Regis G. Granja, Cristina Teixeira, Cassiano Azevedo, Luís |
author_facet | Santos, Mariana M. S. Pereira, Isabel J. Cuboia, Nelson Reis-Pardal, Joana Adrião, Diana Cardoso, Teresa Aragão, Irene Santos, Lurdes Sarmento, António Rosa, Regis G. Granja, Cristina Teixeira, Cassiano Azevedo, Luís |
author_sort | Santos, Mariana M. S. |
collection | PubMed |
description | BACKGROUND: To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy. METHODS: In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients. RESULTS: We observed an overall ICU mortality of 20.1% [95%CI: 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI: 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI: 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI: 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge: hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality. CONCLUSION: Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy. |
format | Online Article Text |
id | pubmed-10621933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106219332023-11-03 Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study Santos, Mariana M. S. Pereira, Isabel J. Cuboia, Nelson Reis-Pardal, Joana Adrião, Diana Cardoso, Teresa Aragão, Irene Santos, Lurdes Sarmento, António Rosa, Regis G. Granja, Cristina Teixeira, Cassiano Azevedo, Luís PLoS One Research Article BACKGROUND: To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy. METHODS: In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients. RESULTS: We observed an overall ICU mortality of 20.1% [95%CI: 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI: 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI: 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI: 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge: hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality. CONCLUSION: Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy. Public Library of Science 2023-11-02 /pmc/articles/PMC10621933/ /pubmed/37917761 http://dx.doi.org/10.1371/journal.pone.0293883 Text en © 2023 Santos et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Santos, Mariana M. S. Pereira, Isabel J. Cuboia, Nelson Reis-Pardal, Joana Adrião, Diana Cardoso, Teresa Aragão, Irene Santos, Lurdes Sarmento, António Rosa, Regis G. Granja, Cristina Teixeira, Cassiano Azevedo, Luís Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title | Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title_full | Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title_fullStr | Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title_full_unstemmed | Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title_short | Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study |
title_sort | predictors of early and long-term mortality after icu discharge in critically ill covid-19 patients: a prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621933/ https://www.ncbi.nlm.nih.gov/pubmed/37917761 http://dx.doi.org/10.1371/journal.pone.0293883 |
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