G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival

Cholesterol derived from the host milieu forms a critical factor for mycobacterial pathogenesis. However, the molecular circuitry co-opted by Mycobacterium tuberculosis (Mtb) to accumulate cholesterol in host cells remains obscure. Here, we report that the coordinated action of WNT-responsive histon...

Descripción completa

Detalles Bibliográficos
Autores principales: Prakhar, Praveen, Bhatt, Bharat, Lohia, Gaurav Kumar, Shah, Awantika, Mukherjee, Tanushree, Kolthur-Seetharam, Ullas, Sundaresan, Nagalingam R., Rajmani, Raju S., Balaji, Kithiganahalli Narayanaswamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621959/
https://www.ncbi.nlm.nih.gov/pubmed/37871034
http://dx.doi.org/10.1371/journal.ppat.1011731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621959/
https://www.ncbi.nlm.nih.gov/pubmed/37871034
http://dx.doi.org/10.1371/journal.ppat.1011731

Ejemplares similares