Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity

Most computational methods that infer somatic copy number alterations (SCNAs) from bulk sequencing of DNA analyse tumour samples individually. However, the sequencing of multiple tumour samples from a patient’s disease is an increasingly common practice. We introduce Refphase, an algorithm that leve...

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Detalles Bibliográficos
Autores principales: Watkins, Thomas B. K., Colliver, Emma C., Huska, Matthew R., Kaufmann, Tom L., Lim, Emilia L., Duncan, Cody B., Haase, Kerstin, Van Loo, Peter, Swanton, Charles, McGranahan, Nicholas, Schwarz, Roland F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621967/
https://www.ncbi.nlm.nih.gov/pubmed/37871126
http://dx.doi.org/10.1371/journal.pcbi.1011379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621967/
https://www.ncbi.nlm.nih.gov/pubmed/37871126
http://dx.doi.org/10.1371/journal.pcbi.1011379

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