Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo

Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and TcdB. The toxins are considered bona fide targets fo...

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Detalles Bibliográficos
Autores principales: Kordus, Shannon L., Kroh, Heather K., Rodríguez, Rubén Cano, Shrem, Rebecca A., Peritore-Galve, F. Christopher, Shupe, John A., Wadzinski, Brian E., Lacy, D. Borden, Spiller, Benjamin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621975/
https://www.ncbi.nlm.nih.gov/pubmed/37871122
http://dx.doi.org/10.1371/journal.ppat.1011496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621975/
https://www.ncbi.nlm.nih.gov/pubmed/37871122
http://dx.doi.org/10.1371/journal.ppat.1011496

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