Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Viral infection triggers the activation of transcription factor IRF3, and its activity is precisely regulated for robust antiviral immune response and effective pathogen clearance. However, how full activation of IRF3 is achieved has not been well defined. Herein, we identified BLK as a key kinase t...

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Detalles Bibliográficos
Autores principales: Li, Wei-Wei, Fan, Xu-Xu, Zhu, Zi-Xiang, Cao, Xue-Jing, Zhu, Zhao-Yu, Pei, Dan-Shi, Wang, Yi-Zhuo, Zhang, Ji-Yan, Wang, Yan-Yi, Zheng, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621992/
https://www.ncbi.nlm.nih.gov/pubmed/37871014
http://dx.doi.org/10.1371/journal.ppat.1011742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621992/
https://www.ncbi.nlm.nih.gov/pubmed/37871014
http://dx.doi.org/10.1371/journal.ppat.1011742

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