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Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response
Viral infection triggers the activation of transcription factor IRF3, and its activity is precisely regulated for robust antiviral immune response and effective pathogen clearance. However, how full activation of IRF3 is achieved has not been well defined. Herein, we identified BLK as a key kinase t...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621992/ https://www.ncbi.nlm.nih.gov/pubmed/37871014 http://dx.doi.org/10.1371/journal.ppat.1011742 |