Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder characterized by cell-type-specific tau lesions in neurons and glia. Prior work uncovered transcriptome changes in human PSP brains, although their cell-specificity is unknown. Further, systematic data integration and...

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Detalles Bibliográficos
Autores principales: Min, Yuhao, Wang, Xue, İş, Özkan, Patel, Tulsi A., Gao, Junli, Reddy, Joseph S., Quicksall, Zachary S., Nguyen, Thuy, Lin, Shu, Tutor-New, Frederick Q., Chalk, Jessica L., Mitchell, Adriana O., Crook, Julia E., Nelson, Peter T., Van Eldik, Linda J., Golde, Todd E., Carrasquillo, Minerva M., Dickson, Dennis W., Zhang, Ke, Allen, Mariet, Ertekin-Taner, Nilüfer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622416/
https://www.ncbi.nlm.nih.gov/pubmed/37919278
http://dx.doi.org/10.1038/s41467-023-42626-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622416/
https://www.ncbi.nlm.nih.gov/pubmed/37919278
http://dx.doi.org/10.1038/s41467-023-42626-3

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