Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases

We studied diverse prenylated intrinsically disordered regions (PIDRs) of Ras and Rho family small GTPases using long timescale atomistic molecular dynamics simulations in an asymmetric model membrane of phosphatidylcholine (PC) and phosphatidylserine (PS) lipids. Here we show that conformational pl...

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Detalles Bibliográficos
Autores principales: Araya, Mussie K., Gorfe, Alemayehu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622456/
https://www.ncbi.nlm.nih.gov/pubmed/37919400
http://dx.doi.org/10.1038/s42003-023-05487-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622456/
https://www.ncbi.nlm.nih.gov/pubmed/37919400
http://dx.doi.org/10.1038/s42003-023-05487-6

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