Glucocorticoids alleviate particulate matter-induced COX-2 expression and mitochondrial dysfunction through the Bcl-2/GR complex in A549 cells

Exposure to particulate matter (PM) causes mitochondrial dysfunction and lung inflammation. The cyclooxygenase-2 (COX-2) pathway is important for inflammation and mitochondrial function. However, the mechanisms by which glucocorticoid receptors (GRs) suppress COX-2 expression during PM exposure have...

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Detalles Bibliográficos
Autores principales: Park, Yeon-Ji, Heo, June, Kim, Yonghyeon, Cho, Hyeseong, Shim, Myeongkuk, Im, Kyunghyun, Lim, Wonchung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622527/
https://www.ncbi.nlm.nih.gov/pubmed/37919369
http://dx.doi.org/10.1038/s41598-023-46257-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622527/
https://www.ncbi.nlm.nih.gov/pubmed/37919369
http://dx.doi.org/10.1038/s41598-023-46257-y

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