Knockout of c-Cbl/Cbl-b slows c-Met trafficking resulting in enhanced signaling in corneal epithelial cells

In many cell types, the E3 ubiquitin ligases c-Cbl and Cbl-b induce ligand-dependent ubiquitylation of the hepatocyte growth factor (HGF)–stimulated c-Met receptor and target it for lysosomal degradation. This study determines whether c-Cbl/Cbl-b are negative regulators of c-Met in the corneal epith...

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Detalles Bibliográficos
Autores principales: Tarvestad-Laise, Kate, Ceresa, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622846/
https://www.ncbi.nlm.nih.gov/pubmed/37690689
http://dx.doi.org/10.1016/j.jbc.2023.105233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622846/
https://www.ncbi.nlm.nih.gov/pubmed/37690689
http://dx.doi.org/10.1016/j.jbc.2023.105233

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