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Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

The AlphaFold Protein Structure Database contains predicted structures for millions of proteins. For the majority of human proteins that contain intrinsically disordered regions (IDRs), which do not adopt a stable structure, it is generally assumed that these regions have low AlphaFold2 confidence s...

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Detalles Bibliográficos
Autores principales: Alderson, T. Reid, Pritišanac, Iva, Kolarić, Đesika, Moses, Alan M., Forman-Kay, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622901/
https://www.ncbi.nlm.nih.gov/pubmed/37878721
http://dx.doi.org/10.1073/pnas.2304302120