Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

PPM1H phosphatase reverses Parkinson’s disease-associated, Leucine Rich Repeat Kinase 2-mediated Rab GTPase phosphorylation. We show here that PPM1H relies on an N-terminal amphipathic helix for Golgi localization. The amphipathic helix enables PPM1H to bind to liposomes in vitro, and small, highly...

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Detalles Bibliográficos
Autores principales: Yeshaw, Wondwossen M., Adhikari, Ayan, Chiang, Claire Y., Dhekne, Herschel S., Wawro, Paulina S., Pfeffer, Suzanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622911/
https://www.ncbi.nlm.nih.gov/pubmed/37889931
http://dx.doi.org/10.1073/pnas.2315171120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622911/
https://www.ncbi.nlm.nih.gov/pubmed/37889931
http://dx.doi.org/10.1073/pnas.2315171120

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