Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation

N(6)-methyladenosine (m(6)A) is the most abundant internal modification on eukaryotic mRNAs. Demethylation of m(6)A on mRNA is catalyzed by the enzyme fat mass and obesity-associated protein (FTO), a member of the nonheme Fe(II) and 2-oxoglutarate (2-OG)-dependent family of dioxygenases. FTO activit...

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Detalles Bibliográficos
Autores principales: Kuschman, Hannah Petraitis, Palczewski, Marianne B., Hoffman, Brian, Menhart, Mary, Wang, Xiaowei, Glynn, Sharon, Islam, Abul B.M.M.K., Benevolenskaya, Elizaveta V., Thomas, Douglas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623363/
https://www.ncbi.nlm.nih.gov/pubmed/37866163
http://dx.doi.org/10.1016/j.redox.2023.102928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623363/
https://www.ncbi.nlm.nih.gov/pubmed/37866163
http://dx.doi.org/10.1016/j.redox.2023.102928

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