Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H(2)O(2), and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells

Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders mediated by poorly understood mechanisms. We herein report that CLZ, while slowing down the morphological changes and lipid accumulation occurri...

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Detalles Bibliográficos
Autores principales: Blandino, Giulia, Fiorani, Mara, Canonico, Barbara, De Matteis, Rita, Guidarelli, Andrea, Montanari, Mariele, Buffi, Gloria, Coppo, Lucia, Arnér, Elias S.J., Cantoni, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623370/
https://www.ncbi.nlm.nih.gov/pubmed/37866162
http://dx.doi.org/10.1016/j.redox.2023.102915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623370/
https://www.ncbi.nlm.nih.gov/pubmed/37866162
http://dx.doi.org/10.1016/j.redox.2023.102915

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