Cargando…

Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease

BACKGROUND: We aim to examine the association between ultra-processed foods (UPF) consumption and cardiovascular disease (CVD) risk and to identify plasma proteins associated with UPF. METHODS: This prospective cohort study included 26,369 participants from the Swedish Malmö Diet and Cancer Study, e...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Huiping, Wang, Yaogang, Sonestedt, Emily, Borné, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623817/
https://www.ncbi.nlm.nih.gov/pubmed/37919714
http://dx.doi.org/10.1186/s12916-023-03111-2
_version_ 1785130816875003904
author Li, Huiping
Wang, Yaogang
Sonestedt, Emily
Borné, Yan
author_facet Li, Huiping
Wang, Yaogang
Sonestedt, Emily
Borné, Yan
author_sort Li, Huiping
collection PubMed
description BACKGROUND: We aim to examine the association between ultra-processed foods (UPF) consumption and cardiovascular disease (CVD) risk and to identify plasma proteins associated with UPF. METHODS: This prospective cohort study included 26,369 participants from the Swedish Malmö Diet and Cancer Study, established in 1991–1996. Dietary intake was assessed using a modified diet history method, and UPF consumption was estimated using the NOVA classification system. A total of 88 selected CVD-related proteins were measured among 4475 subjects. Incident CVD (coronary heart disease and ischemic stroke) was defined as a hospital admission or death through registers. Cox proportional hazards regression models were performed to analyze the associations of UPF intake with risks of CVD. Linear regression models were used to identify the plasma proteins associated with UPF intake. RESULTS: During 24.6 years of median follow-up, 6236 participants developed CVD, of whom 3566 developed coronary heart disease and 3272 developed ischemic stroke. The adjusted hazard ratio (95% confidence interval) in the 4th versus 1st quartile of UPF was 1.18 (1.08, 1.29) for CVD, 1.20 (1.07, 1.35) for coronary heart disease, and 1.17 (1.03, 1.32) for ischemic stroke. Plasma proteins interleukin 18, tumor necrosis factor receptor 2, macrophage colony-stimulating factor 1, thrombomodulin, tumor necrosis factor receptor 1, hepatocyte growth factor, stem cell factor, resistin, C–C motif chemokine 3, and endothelial cell-specific molecule 1 were positively associated with UPF after correcting for multiple testing. CONCLUSIONS: Our study showed that high UPF intake increased the risk of CVD and was associated with several protein biomarkers. Future studies are warranted to validate these findings and assess the potential pathways between UPF intake and CVD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-03111-2.
format Online
Article
Text
id pubmed-10623817
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-106238172023-11-04 Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease Li, Huiping Wang, Yaogang Sonestedt, Emily Borné, Yan BMC Med Research Article BACKGROUND: We aim to examine the association between ultra-processed foods (UPF) consumption and cardiovascular disease (CVD) risk and to identify plasma proteins associated with UPF. METHODS: This prospective cohort study included 26,369 participants from the Swedish Malmö Diet and Cancer Study, established in 1991–1996. Dietary intake was assessed using a modified diet history method, and UPF consumption was estimated using the NOVA classification system. A total of 88 selected CVD-related proteins were measured among 4475 subjects. Incident CVD (coronary heart disease and ischemic stroke) was defined as a hospital admission or death through registers. Cox proportional hazards regression models were performed to analyze the associations of UPF intake with risks of CVD. Linear regression models were used to identify the plasma proteins associated with UPF intake. RESULTS: During 24.6 years of median follow-up, 6236 participants developed CVD, of whom 3566 developed coronary heart disease and 3272 developed ischemic stroke. The adjusted hazard ratio (95% confidence interval) in the 4th versus 1st quartile of UPF was 1.18 (1.08, 1.29) for CVD, 1.20 (1.07, 1.35) for coronary heart disease, and 1.17 (1.03, 1.32) for ischemic stroke. Plasma proteins interleukin 18, tumor necrosis factor receptor 2, macrophage colony-stimulating factor 1, thrombomodulin, tumor necrosis factor receptor 1, hepatocyte growth factor, stem cell factor, resistin, C–C motif chemokine 3, and endothelial cell-specific molecule 1 were positively associated with UPF after correcting for multiple testing. CONCLUSIONS: Our study showed that high UPF intake increased the risk of CVD and was associated with several protein biomarkers. Future studies are warranted to validate these findings and assess the potential pathways between UPF intake and CVD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-03111-2. BioMed Central 2023-11-03 /pmc/articles/PMC10623817/ /pubmed/37919714 http://dx.doi.org/10.1186/s12916-023-03111-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Li, Huiping
Wang, Yaogang
Sonestedt, Emily
Borné, Yan
Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title_full Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title_fullStr Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title_full_unstemmed Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title_short Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
title_sort associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623817/
https://www.ncbi.nlm.nih.gov/pubmed/37919714
http://dx.doi.org/10.1186/s12916-023-03111-2
work_keys_str_mv AT lihuiping associationsofultraprocessedfoodconsumptioncirculatingproteinbiomarkersandriskofcardiovasculardisease
AT wangyaogang associationsofultraprocessedfoodconsumptioncirculatingproteinbiomarkersandriskofcardiovasculardisease
AT sonestedtemily associationsofultraprocessedfoodconsumptioncirculatingproteinbiomarkersandriskofcardiovasculardisease
AT borneyan associationsofultraprocessedfoodconsumptioncirculatingproteinbiomarkersandriskofcardiovasculardisease