4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling

Activation of the mechanistic target of rapamycin complex 1 (mTORC1) contributes to the development of chronic pain. However, the specific mechanisms by which mTORC1 causes hypersensitivity remain elusive. The eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is a key mTORC1 downstream effe...

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Detalles Bibliográficos
Autores principales: Wong, Calvin, Tavares-Ferreira, Diana, Thörn Perez, Carolina, Sharif, Behrang, Uttam, Sonali, Amiri, Mehdi, Lister, Kevin C., Hooshmandi, Mehdi, Nguyen, Vivienne, Séguéla, Philippe, Sonenberg, Nahum, Price, Theodore J., Gkogkas, Christos G., Khoutorsky, Arkady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624345/
https://www.ncbi.nlm.nih.gov/pubmed/37922363
http://dx.doi.org/10.1126/sciadv.adh9603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624345/
https://www.ncbi.nlm.nih.gov/pubmed/37922363
http://dx.doi.org/10.1126/sciadv.adh9603

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