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Search of inhibitors of aldose reductase for treatment of diabetic cataracts using machine learning

PURPOSE: Patients with diabetes mellitus have an elevated chance of developing cataracts, a degenerative vision-impairing condition often needing surgery. The process of the reduction of glucose to sorbitol in the lens of the human eye that causes cataracts is managed by the Aldose Reductase Enzyme...

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Detalles Bibliográficos
Autores principales: Chen, Trevor, Chen, Richard, You, Alvin, Kouznetsova, Valentina L., Tsigelny, Igor F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624573/
https://www.ncbi.nlm.nih.gov/pubmed/37928946
http://dx.doi.org/10.1016/j.aopr.2023.09.002