A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels

Axonal degeneration is a hallmark feature of neurodegenerative diseases. Activation of the NAD(P)ase sterile alpha and toll-interleukin receptor motif containing protein 1 (SARM1) is critical for this process. In resting neurons, SARM1 activity is inhibited, but upon damage, SARM1 is activated and c...

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Detalles Bibliográficos
Autores principales: Icso, Janneke Doedée, Thompson, Paul Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624580/
https://www.ncbi.nlm.nih.gov/pubmed/37742918
http://dx.doi.org/10.1016/j.jbc.2023.105284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624580/
https://www.ncbi.nlm.nih.gov/pubmed/37742918
http://dx.doi.org/10.1016/j.jbc.2023.105284

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