Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells

The hERG1 potassium channel is aberrantly over expressed in tumors and regulates the cancer cell response to integrin-dependent adhesion. We unravel a novel signaling pathway by which integrin engagement by the ECM protein fibronectin promotes hERG1 translocation to the plasma membrane and its assoc...

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Detalles Bibliográficos
Autores principales: Duranti, Claudia, Iorio, Jessica, Bagni, Giacomo, Chioccioli Altadonna, Ginevra, Fillion, Thibault, Lulli, Matteo, D’Alessandro, Franco Nicolas, Montalbano, Alberto, Lastraioli, Elena, Fanelli, Duccio, Coppola, Stefano, Schmidt, Thomas, Piazza, Francesco, Becchetti, Andrea, Arcangeli, Annarosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624597/
https://www.ncbi.nlm.nih.gov/pubmed/37923359
http://dx.doi.org/10.26508/lsa.202302135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624597/
https://www.ncbi.nlm.nih.gov/pubmed/37923359
http://dx.doi.org/10.26508/lsa.202302135

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