Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer

Bispecific T cell engagers (BiTEs), a subset of bispecific antibodies (bsAbs), can promote a targeted cancer cell’s death by bringing it close to a cytotoxic T cell. Checkpoint inhibitory T cell engagers (CiTEs) comprise a BiTE core with an added immunomodulatory protein, which serves to reverse can...

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Detalles Bibliográficos
Autores principales: Szijj, Peter A., Gray, Melissa A., Ribi, Mikaela K., Bahou, Calise, Nogueira, João C. F., Bertozzi, Carolyn R., Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624612/
https://www.ncbi.nlm.nih.gov/pubmed/37488375
http://dx.doi.org/10.1038/s41557-023-01280-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624612/
https://www.ncbi.nlm.nih.gov/pubmed/37488375
http://dx.doi.org/10.1038/s41557-023-01280-4

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