Regulation of eDHFR-tagged proteins with trimethoprim PROTACs

Temporal control of protein levels in cells and living animals can be used to improve our understanding of protein function. In addition, control of engineered proteins could be used in therapeutic applications. PRoteolysis-TArgeting Chimeras (PROTACs) have emerged as a small-molecule-driven strateg...

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Detalles Bibliográficos
Autores principales: Etersque, Jean M., Lee, Iris K., Sharma, Nitika, Xu, Kexiang, Ruff, Andrew, Northrup, Justin D., Sarkar, Swarbhanu, Nguyen, Tommy, Lauman, Richard, Burslem, George M., Sellmyer, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624689/
https://www.ncbi.nlm.nih.gov/pubmed/37923771
http://dx.doi.org/10.1038/s41467-023-42820-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624689/
https://www.ncbi.nlm.nih.gov/pubmed/37923771
http://dx.doi.org/10.1038/s41467-023-42820-3

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