The Pharmacokinetic Profile of Palovarotene: An Open-Label Phase I Trial Investigating the Effect of Food and Potential for Drug–Drug Interaction in Healthy Participants

BACKGROUND AND OBJECTIVES: Palovarotene is under development for the treatment of fibrodysplasia ossificans progressiva (FOP). The objectives of this study were to evaluate palovarotene pharmacokinetics under fed versus fasted conditions and its induction potential towards cytochrome P450 3A4 (CYP3A...

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Detalles Bibliográficos
Autores principales: Marino, Rose, Dube, Louise, Ogier, Julien, Le Quan Sang, Kim-Hanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624720/
https://www.ncbi.nlm.nih.gov/pubmed/37804430
http://dx.doi.org/10.1007/s13318-023-00856-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624720/
https://www.ncbi.nlm.nih.gov/pubmed/37804430
http://dx.doi.org/10.1007/s13318-023-00856-2

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