Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by (99m)Tc radiolabeling technique

Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp efflux transporters susceptibility, and limited (≈40%) oral bioavailability. Transdermal route of administration c...

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Detalles Bibliográficos
Autores principales: Tawfik, Mai Ahmed, Eltaweel, Mai M., Fatouh, Ahmed M., Shamsel-Din, Hesham A., Ibrahim, Ahmed B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624728/
https://www.ncbi.nlm.nih.gov/pubmed/37273147
http://dx.doi.org/10.1007/s13346-023-01373-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624728/
https://www.ncbi.nlm.nih.gov/pubmed/37273147
http://dx.doi.org/10.1007/s13346-023-01373-0

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