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Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by (99m)Tc radiolabeling technique
Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp efflux transporters susceptibility, and limited (≈40%) oral bioavailability. Transdermal route of administration c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624728/ https://www.ncbi.nlm.nih.gov/pubmed/37273147 http://dx.doi.org/10.1007/s13346-023-01373-0 |