In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4(+) T cells

Blockade of the immune checkpoint axis consisting of programmed death-1 (PD-1) and its ligand PD-L1 alleviates the functional inhibition of tumor-infiltrating lymphoid cells yet weakly induces their expansion. Exogenous cytokines could further expand lymphoid cells and thus synergize with αPD-L1 the...

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Detalles Bibliográficos
Autores principales: Awad, Robin Maximilian, De Vlaeminck, Yannick, Meeus, Fien, Ertveldt, Thomas, Zeven, Katty, Ceuppens, Hannelore, Goyvaerts, Cleo, Verdonck, Magali, Salguero, Gustavo, Raes, Geert, Devoogdt, Nick, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624833/
https://www.ncbi.nlm.nih.gov/pubmed/37923822
http://dx.doi.org/10.1038/s41598-023-45948-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624833/
https://www.ncbi.nlm.nih.gov/pubmed/37923822
http://dx.doi.org/10.1038/s41598-023-45948-w

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