Structure–activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association with invasive disease, little is known about enzymatic function beyond the ELR(+) CXC chemokine substrate range. As a serine protease, SpyCEP has...

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Detalles Bibliográficos
Autores principales: Pearson, Max, Haslam, Carl, Fosberry, Andrew, Jones, Emma J., Reglinski, Mark, Reeves, Lucy, Edwards, Robert J., Lawrenson, Richard Ashley, Brown, Jonathan C., Mossakowska, Danuta, Pease, James Edward, Sriskandan, Shiranee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624844/
https://www.ncbi.nlm.nih.gov/pubmed/37923786
http://dx.doi.org/10.1038/s41598-023-46036-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624844/
https://www.ncbi.nlm.nih.gov/pubmed/37923786
http://dx.doi.org/10.1038/s41598-023-46036-9

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