DNA strand breaks and gaps target retroviral intasome binding and integration

Retrovirus integration into a host genome is essential for productive infections. The integration strand transfer reaction is catalyzed by a nucleoprotein complex (Intasome) containing the viral integrase (IN) and the reverse transcribed (RT) copy DNA (cDNA). Previous studies suggested that DNA targ...

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Detalles Bibliográficos
Autores principales: Senavirathne, Gayan, London, James, Gardner, Anne, Fishel, Richard, Yoder, Kristine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624929/
https://www.ncbi.nlm.nih.gov/pubmed/37923737
http://dx.doi.org/10.1038/s41467-023-42641-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624929/
https://www.ncbi.nlm.nih.gov/pubmed/37923737
http://dx.doi.org/10.1038/s41467-023-42641-4

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