A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be soluble and aggregated in the central ner...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625127/
https://www.ncbi.nlm.nih.gov/pubmed/37688357
http://dx.doi.org/10.1002/advs.202301120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625127/
https://www.ncbi.nlm.nih.gov/pubmed/37688357
http://dx.doi.org/10.1002/advs.202301120

Ejemplares similares