A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

BACKGROUND: People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of...

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Detalles Bibliográficos
Autores principales: Lee, Jin-Gu, Fu, Yulong, Zhu, Jun-yi, Wen, Pei, van de Leemput, Joyce, Ray, Patricio E., Han, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625211/
https://www.ncbi.nlm.nih.gov/pubmed/37925499
http://dx.doi.org/10.1186/s13578-023-01147-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625211/
https://www.ncbi.nlm.nih.gov/pubmed/37925499
http://dx.doi.org/10.1186/s13578-023-01147-8

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