Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments

Clinical implementation of new prediction models requires evaluation of their utility in a broad range of intended use populations. Here we develop and validate ancestry-specific Polygenic Risk Scores (PRSs) for Coronary Artery Disease (CAD) using 29,389 individuals from diverse cohorts and genetic...

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Detalles Bibliográficos
Autores principales: Busby, George B., Kulm, Scott, Bolli, Alessandro, Kintzle, Jen, Domenico, Paolo Di, Bottà, Giordano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625612/
https://www.ncbi.nlm.nih.gov/pubmed/37925478
http://dx.doi.org/10.1038/s41467-023-42897-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625612/
https://www.ncbi.nlm.nih.gov/pubmed/37925478
http://dx.doi.org/10.1038/s41467-023-42897-w

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