Complement and platelets: prothrombotic cell activation requires membrane attack complex–induced release of danger signals

Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events, which are largely refractory to anticoagulation and/or antiplatelet therapy. Anticomplement therapy, however, efficiently pr...

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Detalles Bibliográficos
Autores principales: Mannes, Marco, Pechtl, Veronika, Hafner, Susanne, Dopler, Arthur, Eriksson, Oskar, Manivel, Vivek Anand, Wohlgemuth, Lisa, Messerer, David Alexander Christian, Schrezenmeier, Hubert, Ekdahl, Kristina N., Nilsson, Bo, Jacobsen, Eva-Maria, Hoenig, Manfred, Huber-Lang, Markus, Braun, Christian K., Schmidt, Christoph Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625899/
https://www.ncbi.nlm.nih.gov/pubmed/37428869
http://dx.doi.org/10.1182/bloodadvances.2023010817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625899/
https://www.ncbi.nlm.nih.gov/pubmed/37428869
http://dx.doi.org/10.1182/bloodadvances.2023010817

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