Human wild‐type and D76N β(2)‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

β(2)‐microglobulin (β(2)‐m) is a plasma protein derived from physiological shedding of the class I major histocompatibility complex (MHCI), causing human systemic amyloidosis either due to persistently high concentrations of the wild‐type (WT) protein in hemodialyzed patients, or in presence of muta...

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Detalles Bibliográficos
Autores principales: Raimondi, Sara, Faravelli, Giulia, Nocerino, Paola, Mondani, Valentina, Baruffaldi, Alma, Marchese, Loredana, Mimmi, Maria Chiara, Canetti, Diana, Verona, Guglielmo, Caterino, Marianna, Ruoppolo, Margherita, Mangione, P. Patrizia, Bellotti, Vittorio, Lavatelli, Francesca, Giorgetti, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626158/
https://www.ncbi.nlm.nih.gov/pubmed/37936921
http://dx.doi.org/10.1096/fba.2023-00073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626158/
https://www.ncbi.nlm.nih.gov/pubmed/37936921
http://dx.doi.org/10.1096/fba.2023-00073

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