Insulin C-peptide secretion on-a-chip to measure the dynamics of secretion and metabolism from individual islets

First-phase glucose-stimulated insulin secretion is mechanistically linked to type 2 diabetes, yet the underlying metabolism is difficult to discern due to significant islet-to-islet variability. Here, we miniaturize a fluorescence anisotropy immunoassay onto a microfluidic device to measure C-pepti...

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Detalles Bibliográficos
Autores principales: Wang, Yufeng, Regeenes, Romario, Memon, Mahnoor, Rocheleau, Jonathan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626205/
https://www.ncbi.nlm.nih.gov/pubmed/37820726
http://dx.doi.org/10.1016/j.crmeth.2023.100602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626205/
https://www.ncbi.nlm.nih.gov/pubmed/37820726
http://dx.doi.org/10.1016/j.crmeth.2023.100602

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