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Insulin C-peptide secretion on-a-chip to measure the dynamics of secretion and metabolism from individual islets
First-phase glucose-stimulated insulin secretion is mechanistically linked to type 2 diabetes, yet the underlying metabolism is difficult to discern due to significant islet-to-islet variability. Here, we miniaturize a fluorescence anisotropy immunoassay onto a microfluidic device to measure C-pepti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626205/ https://www.ncbi.nlm.nih.gov/pubmed/37820726 http://dx.doi.org/10.1016/j.crmeth.2023.100602 |