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Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to en...

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Autores principales: Patil, Leena, Verma, Umakant, Rajput, Rahul, Patil, Pritam, Chaterjee, Aniruddha, Naik, Jitendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626510/
https://www.ncbi.nlm.nih.gov/pubmed/37937245
http://dx.doi.org/10.5599/admet.1998
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author Patil, Leena
Verma, Umakant
Rajput, Rahul
Patil, Pritam
Chaterjee, Aniruddha
Naik, Jitendra
author_facet Patil, Leena
Verma, Umakant
Rajput, Rahul
Patil, Pritam
Chaterjee, Aniruddha
Naik, Jitendra
author_sort Patil, Leena
collection PubMed
description INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to enhance the drug solubility. METHOD: The solid dispersion of olanzapine is prepared by spray drying technique. The solution of polyvinylpyrrolidone K-30 (PVP K-30), mono amino glycyrrhizinate pentahydrate (GLY), OLZ and silicon dioxide were dissolved in distilled water and ethanol and spray dried to get the solid dispersion. Solid dispersion was characterized for surface morphology, solubility, encapsulation efficiency (EE), X-ray diffraction (X-RD), Differential Scanning Calorimeter (DSC) and drug-polymer interaction by Fourier transforms infrared spectroscopy. RESULTS: The amorphous nature of the drug's incorporation in solid dispersion was confirmed by X-RD analysis. Prepared solid dispersion showed higher solubility, 11.51 mg, than pure OLZ (0.983 mg ml(-1)), while the range of EE was found to be between 64 to 90 %. CONCLUSIONS: The solubility and dissolution rate of the OLZ can effectively increase by spray-dried solid dispersion. Plackett–Burman screening design plays a vital role in understanding the effect of independent variables on EE and solubility.
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spelling pubmed-106265102023-11-07 Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement Patil, Leena Verma, Umakant Rajput, Rahul Patil, Pritam Chaterjee, Aniruddha Naik, Jitendra ADMET DMPK Original Scientific Paper INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to enhance the drug solubility. METHOD: The solid dispersion of olanzapine is prepared by spray drying technique. The solution of polyvinylpyrrolidone K-30 (PVP K-30), mono amino glycyrrhizinate pentahydrate (GLY), OLZ and silicon dioxide were dissolved in distilled water and ethanol and spray dried to get the solid dispersion. Solid dispersion was characterized for surface morphology, solubility, encapsulation efficiency (EE), X-ray diffraction (X-RD), Differential Scanning Calorimeter (DSC) and drug-polymer interaction by Fourier transforms infrared spectroscopy. RESULTS: The amorphous nature of the drug's incorporation in solid dispersion was confirmed by X-RD analysis. Prepared solid dispersion showed higher solubility, 11.51 mg, than pure OLZ (0.983 mg ml(-1)), while the range of EE was found to be between 64 to 90 %. CONCLUSIONS: The solubility and dissolution rate of the OLZ can effectively increase by spray-dried solid dispersion. Plackett–Burman screening design plays a vital role in understanding the effect of independent variables on EE and solubility. International Association of Physical Chemists 2023-10-06 /pmc/articles/PMC10626510/ /pubmed/37937245 http://dx.doi.org/10.5599/admet.1998 Text en Copyright © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Original Scientific Paper
Patil, Leena
Verma, Umakant
Rajput, Rahul
Patil, Pritam
Chaterjee, Aniruddha
Naik, Jitendra
Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title_full Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title_fullStr Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title_full_unstemmed Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title_short Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
title_sort development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
topic Original Scientific Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626510/
https://www.ncbi.nlm.nih.gov/pubmed/37937245
http://dx.doi.org/10.5599/admet.1998
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