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Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement
INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to en...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Association of Physical Chemists
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626510/ https://www.ncbi.nlm.nih.gov/pubmed/37937245 http://dx.doi.org/10.5599/admet.1998 |
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author | Patil, Leena Verma, Umakant Rajput, Rahul Patil, Pritam Chaterjee, Aniruddha Naik, Jitendra |
author_facet | Patil, Leena Verma, Umakant Rajput, Rahul Patil, Pritam Chaterjee, Aniruddha Naik, Jitendra |
author_sort | Patil, Leena |
collection | PubMed |
description | INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to enhance the drug solubility. METHOD: The solid dispersion of olanzapine is prepared by spray drying technique. The solution of polyvinylpyrrolidone K-30 (PVP K-30), mono amino glycyrrhizinate pentahydrate (GLY), OLZ and silicon dioxide were dissolved in distilled water and ethanol and spray dried to get the solid dispersion. Solid dispersion was characterized for surface morphology, solubility, encapsulation efficiency (EE), X-ray diffraction (X-RD), Differential Scanning Calorimeter (DSC) and drug-polymer interaction by Fourier transforms infrared spectroscopy. RESULTS: The amorphous nature of the drug's incorporation in solid dispersion was confirmed by X-RD analysis. Prepared solid dispersion showed higher solubility, 11.51 mg, than pure OLZ (0.983 mg ml(-1)), while the range of EE was found to be between 64 to 90 %. CONCLUSIONS: The solubility and dissolution rate of the OLZ can effectively increase by spray-dried solid dispersion. Plackett–Burman screening design plays a vital role in understanding the effect of independent variables on EE and solubility. |
format | Online Article Text |
id | pubmed-10626510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Association of Physical Chemists |
record_format | MEDLINE/PubMed |
spelling | pubmed-106265102023-11-07 Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement Patil, Leena Verma, Umakant Rajput, Rahul Patil, Pritam Chaterjee, Aniruddha Naik, Jitendra ADMET DMPK Original Scientific Paper INTRODUCTION: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to enhance the drug solubility. METHOD: The solid dispersion of olanzapine is prepared by spray drying technique. The solution of polyvinylpyrrolidone K-30 (PVP K-30), mono amino glycyrrhizinate pentahydrate (GLY), OLZ and silicon dioxide were dissolved in distilled water and ethanol and spray dried to get the solid dispersion. Solid dispersion was characterized for surface morphology, solubility, encapsulation efficiency (EE), X-ray diffraction (X-RD), Differential Scanning Calorimeter (DSC) and drug-polymer interaction by Fourier transforms infrared spectroscopy. RESULTS: The amorphous nature of the drug's incorporation in solid dispersion was confirmed by X-RD analysis. Prepared solid dispersion showed higher solubility, 11.51 mg, than pure OLZ (0.983 mg ml(-1)), while the range of EE was found to be between 64 to 90 %. CONCLUSIONS: The solubility and dissolution rate of the OLZ can effectively increase by spray-dried solid dispersion. Plackett–Burman screening design plays a vital role in understanding the effect of independent variables on EE and solubility. International Association of Physical Chemists 2023-10-06 /pmc/articles/PMC10626510/ /pubmed/37937245 http://dx.doi.org/10.5599/admet.1998 Text en Copyright © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Original Scientific Paper Patil, Leena Verma, Umakant Rajput, Rahul Patil, Pritam Chaterjee, Aniruddha Naik, Jitendra Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title | Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title_full | Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title_fullStr | Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title_full_unstemmed | Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title_short | Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
title_sort | development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement |
topic | Original Scientific Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626510/ https://www.ncbi.nlm.nih.gov/pubmed/37937245 http://dx.doi.org/10.5599/admet.1998 |
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