Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a model system and compared them to colon epithelia...

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Detalles Bibliográficos
Autores principales: Holst, Mikkel Roland, de Wit, Nienke Marije, Ozgür, Burak, Brachner, Andreas, Hyldig, Kathrine, Appelt-Menzel, Antje, Sleven, Hannah, Cader, Zameel, de Vries, Helga Eveline, Neuhaus, Winfried, Jensen, Allan, Brodin, Birger, Nielsen, Morten Schallburg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626680/
https://www.ncbi.nlm.nih.gov/pubmed/37932749
http://dx.doi.org/10.1186/s12987-023-00480-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626680/
https://www.ncbi.nlm.nih.gov/pubmed/37932749
http://dx.doi.org/10.1186/s12987-023-00480-x

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