CRISPR-screen identifies ZIP9 and dysregulated Zn(2+) homeostasis as a cause of cancer-associated changes in glycosylation

INTRODUCTION: In epithelial cancers, truncated O-glycans, such as the Thomson-nouveau antigen (Tn) and its sialylated form (STn), are upregulated on the cell surface and associated with poor prognosis and immunological escape. Recent studies have shown that these carbohydrate epitopes facilitate can...

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Detalles Bibliográficos
Autores principales: Rømer, Troels Boldt, Khoder-Agha, Fawzi, Aasted, Mikkel Koed Møller, de Haan, Noortje, Horn, Sabrina, Dylander, August, Zhang, Tao, Pallesen, Emil Marek Heymans, Dabelsteen, Sally, Wuhrer, Manfred, Høgsbro, Christine Flodgaard, Thomsen, Emil Aagaard, Mikkelsen, Jacob Giehm, Wandall, Hans H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627246/
https://www.ncbi.nlm.nih.gov/pubmed/36648436
http://dx.doi.org/10.1093/glycob/cwad003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627246/
https://www.ncbi.nlm.nih.gov/pubmed/36648436
http://dx.doi.org/10.1093/glycob/cwad003

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