Cargando…

Model Organism Modifier (MOM): a user-friendly Galaxy workflow to detect modifiers from genome sequencing data using Caenorhabditis elegans

Genetic modifiers are variants modulating phenotypic outcomes of a primary detrimental variant. They contribute to rare diseases phenotypic variability, but their identification is challenging. Genetic screening with model organisms is a widely used method for demystifying genetic modifiers. Forward...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maroilley, Tatiana, Rahit, K M Tahsin Hassan, Chida, Afiya Razia, Cotra, Filip, Rodrigues Alves Barbosa, Victoria, Tarailo-Graovac, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Software and Data Resources
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627290/ https://www.ncbi.nlm.nih.gov/pubmed/37585487 http://dx.doi.org/10.1093/g3journal/jkad184

Ejemplares similares

Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements
por: Maroilley, Tatiana, et al.
Publicado: (2023)

Genetic Modifiers and Rare Mendelian Disease
por: Rahit, K. M. Tahsin Hassan, et al.
Publicado: (2020)

Molecular basis of essential and morphological variations across 12 balancer strains in C. elegans
por: Cotra, Filip, et al.
Publicado: (2023)

Whole genome sequencing facilitates intragenic variant interpretation following modifier screening in C. elegans
por: Jean, Francesca, et al.
Publicado: (2021)

Uncovering Missing Heritability in Rare Diseases
por: Maroilley, Tatiana, et al.
Publicado: (2019)

OPPL-Galaxy, a Galaxy tool for enhancing ontology exploitation as part of bioinformatics workflows
por: Aranguren, Mikel Egaña, et al.
Publicado: (2013)

The Power of Clinical Diagnosis for Deciphering Complex Genetic Mechanisms in Rare Diseases
por: Shu, Li, et al.
Publicado: (2023)

Proper Cyclin B3 Dosage Is Important for Precision of Metaphase-to-Anaphase Onset Timing in Caenorhabditis elegans
por: Tarailo-Graovac, Maja, et al.
Publicado: (2012)

Mos1-Mediated Transgenesis to Probe Consequences of Single Gene Mutations in Variation-Rich Isolates of Caenorhabditis elegans
por: Tarailo-Graovac, Maja, et al.
Publicado: (2012)

Tavaxy: Integrating Taverna and Galaxy workflows with cloud computing support
por: Abouelhoda, Mohamed, et al.
Publicado: (2012)

GCAC: galaxy workflow system for predictive model building for virtual screening
por: Bharti, Deepak R., et al.
Publicado: (2019)

The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform
por: Bray, Simon A., et al.
Publicado: (2020)

Osiris: accessible and reproducible phylogenetic and phylogenomic analyses within the Galaxy workflow management system
por: Oakley, Todd H, et al.
Publicado: (2014)

Deciphering complex genome rearrangements in C. elegans using short-read whole genome sequencing
por: Maroilley, Tatiana, et al.
Publicado: (2021)

CeMbio - The Caenorhabditis elegans Microbiome Resource
por: Dirksen, Philipp, et al.
Publicado: (2020)

CeAid: a smartphone application for logging and plotting Caenorhabditis elegans assays
por: Sohrabi, Salman, et al.
Publicado: (2021)

Polymorphic segmental duplication in the nematode Caenorhabditis elegans
por: Vergara, Ismael A, et al.
Publicado: (2009)

Recompleting the Caenorhabditis elegans genome
por: Yoshimura, Jun, et al.
Publicado: (2019)

Rare disorders have many faces: in silico characterization of rare disorder spectrum
por: Frederiksen, Simona D., et al.
Publicado: (2022)

Galaxy Integrated Omics: Web-based Standards-Compliant Workflows for Proteomics Informed by Transcriptomics
por: Fan, Jun, et al.
Publicado: (2015)

Reusable, extensible, and modifiable R scripts and Kepler workflows for comprehensive single set ChIP-seq analysis
por: Cormier, Nathan, et al.
Publicado: (2016)

MetaDEGalaxy: Galaxy workflow for differential abundance analysis of 16s metagenomic data
por: Thang, Mike W.C., et al.
Publicado: (2019)

Executing SADI services in Galaxy
por: Aranguren, Mikel Egaña, et al.
Publicado: (2014)

ARMOR: An Automated Reproducible MOdular Workflow for Preprocessing and Differential Analysis of RNA-seq Data
por: Orjuela, Stephany, et al.
Publicado: (2019)

Integrative meta-omics in Galaxy and beyond
por: Schiml, Valerie C., et al.
Publicado: (2023)

Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans
por: Wang, Xueqing, et al.
Publicado: (2022)

Genome-wide variations in a natural isolate of the nematode Caenorhabditis elegans
por: Vergara, Ismael A, et al.
Publicado: (2014)

A user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal
por: Eijssen, Lars M.T., et al.
Publicado: (2015)

Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans
por: Tarailo-Graovac, Maja, et al.
Publicado: (2010)

Nanopore-based direct sequencing of RNA transcripts with 10 different modified nucleotides reveals gaps in existing technology
por: Burdick, Joshua T, et al.
Publicado: (2023)

The million mutation project: A new approach to genetics in Caenorhabditis elegans
por: Thompson, Owen, et al.
Publicado: (2013)

The Planemo toolkit for developing, deploying, and executing scientific data analyses in Galaxy and beyond
por: Bray, Simon, et al.
Publicado: (2023)

Transformer-based tool recommendation system in Galaxy
por: Kumar, Anup, et al.
Publicado: (2023)

Comprehensive characterization of tissue-specific chromatin accessibility in L2 Caenorhabditis elegans nematodes
por: Durham, Timothy J., et al.
Publicado: (2021)

Cluster Flow: A user-friendly bioinformatics workflow tool
por: Ewels, Philip, et al.
Publicado: (2017)

The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-Caenorhabditis nematodes
por: Bryant, Astra S, et al.
Publicado: (2021)

Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation
por: Tarailo-Graovac, Maja, et al.
Publicado: (2015)

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans
por: Frommolt, Peter, et al.
Publicado: (2015)

Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans
por: Chu, Jeffery S. C., et al.
Publicado: (2012)

An atlas of Caenorhabditis elegans chemoreceptor expression
por: Vidal, Berta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lrbts4elmdmjcvvn0tmp3if3sh