High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope

A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaques; yet serum from only two animals neutralized th...

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Detalles Bibliográficos
Autores principales: Mopuri, Rohini, Welbourn, Sarah, Charles, Tysheena, Ralli-Jain, Pooja, Rosales, David, Burton, Samantha, Aftab, Areeb, Karunakaran, Kirti, Pellegrini, Kathryn, Kilembe, William, Karita, Etienne, Gnanakaran, Sandrasegaram, Upadhyay, Amit A., Bosinger, Steven E., Derdeyn, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627474/
https://www.ncbi.nlm.nih.gov/pubmed/37878666
http://dx.doi.org/10.1371/journal.ppat.1011717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627474/
https://www.ncbi.nlm.nih.gov/pubmed/37878666
http://dx.doi.org/10.1371/journal.ppat.1011717

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