Neuronal activation of G(αq) EGL-30/GNAQ late in life rejuvenates cognition across species

Loss of cognitive function with age is devastating. EGL-30/GNAQ and G(αq) signaling pathways are highly conserved between C. elegans and mammals, and murine Gnaq is enriched in hippocampal neurons and declines with age. We found that activation of EGL-30 in aged worms triples memory span, and GNAQ g...

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Detalles Bibliográficos
Autores principales: Stevenson, Morgan E., Bieri, Gregor, Kaletsky, Rachel, St. Ange, Jonathan, Remesal, L., Pratt, Karishma J.B., Zhou, Shiyi, Weng, Yifei, Murphy, Coleen T., Villeda, Saul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627507/
https://www.ncbi.nlm.nih.gov/pubmed/37713310
http://dx.doi.org/10.1016/j.celrep.2023.113151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627507/
https://www.ncbi.nlm.nih.gov/pubmed/37713310
http://dx.doi.org/10.1016/j.celrep.2023.113151

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